Chlorhexidine digluconate

Chlorhexidine is a widely used antiseptic that is intended for topical use.

The drug has an effect on gram-negative and gram-positive bacteria, eliminating the development of the inflammatory process in the tissues of the body. Differs in stable properties. After application, it remains active, and provides a bactericidal effect for a long time. This is one of the most common and safe means. The solution is capable of stopping the activity of many grampe and gramminus pathogens.

Allowed for use during pregnancy, it is possible to treat wounds to children, to be used in gynecology, dentistry for rinsing the mouth and throat, and venereal practice.

Clinico-pharmacological group


Terms of sale from pharmacies

Can be bought without a doctor's prescription.


How much is Chlorhexidine digluconate in pharmacies? The average price is at the level of 20 rubles.

Composition and release form

Name - Chlorhexidine (Chlorhexidine). Available in the form of a solution for external use 0.05% and 20%. Also in the form of candles, gels, sprays and ointments.

  • A solution of 0.05% Chlorhexidine is provided in a polymer vial with a nozzle or glass vials of 100 ml. Packaging for the drug is used cardboard type. In such a carton is 1 bottle.

A solution of 20% Chlorhexidine is available in polymer bottles with a cap, the content of 100 or 500 ml.

Pharmacological effect

Microorganisms Chlorhexidine digluconate - this salt is used as an antiseptic - acts differently and depends on the type of microbes.

  1. Mushrooms. The effect of the drug on pathogenic and opportunistic fungi is very similar to the effect on bacteria. Destroying the cell wall, antiseptic penetrates into the cytoplasmic membrane of the fungus and irrevocably ruins the cell.
  2. Bacteria. The positively charged chlorhexidine molecule binds to the cell wall of bacteria that has a negative charge. As a result, destabilization and damage to the cell wall occurs. Interestingly, this process takes only about 20 seconds. However, the role of the antiseptic does not end there. The drug penetrates into the cell and attacks the internal cytoplasmic membrane of the bacterium, as a result of which the contents simply flow into the cytoplasm. The cage is dying. Chlorhexidine bigluconate high concentration can cause solidification or hardening of the cytoplasm.
  3. Biofilm. This is a complex set of microorganisms growing on a solid organic (for example, dental plaque) or inorganic surface. Biofilms are characterized by structural heterogeneity, genetic diversity, and complex interactions within the conglomerate. The matrix protects the cells inside it, which causes the biofilm microorganisms to be particularly resistant to antibacterial drugs. Most antiseptics are not able to operate within the complex structure of a biofilm. Chlorhexidine was knocked out of a slim number of impotent relatives and in which he proved his exceptional abilities. The drug can prevent the adhesion (sticking) of microorganisms to a solid surface, as a result of which the growth and development of biofilm stops.
  4. Other microorganisms. Unlike many antiseptics, Chlorhexidine solution shows high efficiency against other microbes, for example, bacterial spores and protozoa. It is assumed that it also acts against viruses covered by an additional envelope: herpes simplex virus, HIV, cytomegalovirus, influenza virus. Non-enveloped viruses are resistant to Chlorhexidine. Among them are the causative agents of SARS, rotavirus, adenovirus and enteroviruses.

Indications for use

Chlorhexidine digluconate is intended for therapeutic measures in the fight against pathologies caused by pathogens susceptible to its action:

A solution of 0.1% (0.05 and 0.2):

  • appointed for prophylactic purposes after surgical interventions and for injuries in dentistry, laryngiotrhinological organs.
  • when disinfecting the damaged mucous membranes of the mouth and genitals.
  • treatment of integuments to prevent infection after manipulations in surgical, obstetric practice and gynecology.
  • as an antiseptic for wound areas, scratches, abrasions, cuts and burns.
  • to protect against viruses that penetrate the urethrogenital system.
  • for gargling.

Solution 0, 5%:

  • for surface treatment, devices and instruments of medical purpose in a heated to 750With the state.

Solution 1%:

  • preventive measures for burn injuries of the epidermis.
  • for disinfection and cleaning the hands of doctors and staff before the operation.

There is also a solution with a concentration of 5 and 20% for the preparation of the composition with the use of alcohol, glycerin or water.


Chlorhexidine 0.05% can not be used:

  • for the treatment of patients with dermatitis;
  • for disinfection after operations on the central nervous system and the auditory canal;
  • for the treatment of ophthalmic diseases;
  • simultaneously with other antiseptics.

With caution, the drug is used in children.

Appointment during pregnancy and lactation

The drug Chlorhexidine, if necessary, can be used to treat pregnant women. In the course of clinical trials, no teratogenic or embryotoxic effect of the drug on the child's body was detected, even if the solution was used in the first weeks of pregnancy.

Chlorhexidine solution can be used by pregnant women immediately for 1-2 weeks before delivery for the purpose of rehabilitation of the birth canal and treatment of colpitis, vaginitis, thrush.

The drug Chlorhexidine Bigluconta can be used externally and topically to nursing mothers. For this, it is not necessary to interrupt lactation.

Dosage and method of use

As indicated in the instructions for use Chlorhexidine digluconate solution is used externally, topically.

Solution for local and external use of 0.2%, solution for external use of 0.05%

On the affected surface of the skin or mucous membranes of the oral cavity, urinary organs, 5-10 ml of the preparation is applied by irrigation or a swab and left for 1-3 minutes. Frequency of use - 2-3 times a day.

For the prevention of sexually transmitted diseases, the contents of the vial are inserted into the vagina by women (5-10 ml) or into the urethra by men (2-3 ml) and women (1-2 ml) for 2-3 minutes through a nozzle. It is recommended not to urinate for 2 hours after the procedure. Also, the drug should treat the skin of the genital organs, pubis, inner thighs.

Solution for local and external use of 0,5%

5-10 ml of the drug in the form of rinses, applications or irrigations applied to the affected surface of the skin or mucous membranes and leave for 1-3 minutes. Frequency of use - 2-3 times a day.

Medical equipment and work surfaces are treated with a sponge moistened with a solution or by soaking.

Solution for local and external use of 1%

The skin of postoperative wounds is treated with a solution using a clean tampon.

Before processing the preparation, the surgeon's hands are washed thoroughly with soap and wipe dry, after which they are washed with 20-30 ml of solution. Postoperative wounds are treated with a clean tampon.

Work surfaces and medical instruments are treated with a clean sponge or a soaking wetted solution.

Solution for local and external use of 5%

Dilution of the concentrate is carried out based on the calculation of the concentration of the prepared solution.

Adverse reactions

When Chlorhexidine Bigluconate was used in the treatment process, some patients had the following side effects:

  • dry skin;
  • itchy skin;
  • rash;
  • dermatitis;
  • photosensitivity.

With prolonged use of the means for rinsing and irrigation of the oral cavity, taste sensations may change, tartar appears, teeth change is noted.


In case of compliance with the instructions, overdose with chlorhexidine is excluded. If a person accidentally swallows the drug, you should immediately wash the stomach, using milk, raw egg, gelatin or soap.

Special instructions

Remains active in the presence of blood and organic matter. Chlorhexidine should not be allowed to enter the eyes (with the exception of a special dosage form intended for washing the eyes), as well as contact with the meninges and the auditory nerve.

Compatibility with other drugs

When using the drug, you must consider the interaction with other drugs:

  1. Ethyl alcohol enhances the bactericidal effect.
  2. Not compatible with anionic compounds, in particular with soap.
  3. Not compatible with chlorides, carbonates, phosphates, sulfates, borates, citrates.
  4. Under the influence of the drug, the sensitivity of microorganisms to the effects of neomycin, kanamycin, chloramphenicol, cephalosporin increases.
  5. If the pH of the medium exceeds 8, a precipitate falls. If hard water was used in the preparation of the solution, its bactericidal effect is reduced.


We offer you to read the reviews of people who used Chlorhexidine digluconate:

  1. Ulyana. I have been using Chlorhexidine for a very long time, the main purpose of the application is skin treatment. I have a problem type, acne and rashes often appear. Every evening I wipe my face with a solution of 0.05% and apply a cream. I like that the tool dries pimples quickly and prevents them from spreading further. All my girlfriends are also so enjoyed, satisfied.
  2. Victoria. A good means for disinfection, especially after squeezing and opening pimples, because it does not paint and does not burn. Some of them get rid of acne, but so far Metrogil is fine with me. And in the summer you can wipe your face with chlorhexidine to prevent acne.
  3. Alexander. Last week I had a tooth removed. Until they put on the crown, they said to leave until healing and gently rinse Chlorhexidine’s mouth once a day to kill the possible microflora and not inflict another infection. The drug is a bit bitter to the taste, but does not cause unpleasant feelings and discomfort when used. I rinse them for the third day, it seems to be healing.


No full analogues. In most cases, Miramistin can be used as a counterpart.

Which is better: Chlorhexidine or Miramistin?

Many people are convinced that it is the same medication. In fact, they really belong to the same class of antiseptic. What is the difference between Chlorhexidine and Miramistin - it is in the active substances contained in the preparations.

Miramistin is not a complete analogue of Chlorhexidine. It has a pronounced antifungal and antiviral effect. Therefore, there are some differences in the indications for use of this drug. Miramistin is not contraindicated for people suffering from dermatitis.

Shelf life and storage conditions

Store the bottle with the solution in a dark place away from children at a temperature not higher than 30 degrees. The shelf life of the drug is 2 years from the date of manufacture, after opening the bottle, the solution must be used within 6 months.

Watch the video: Chlorhexidine Gluconate Peridex Oral Rinse Review! Helps prevent Dry Socket! (January 2020).


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