Regulon is a contraceptive containing estrogen and progestogen. The drug has a contraceptive, estrogen-progestogenic effects.

It is characterized by the ability to inhibit the production of gonadotropin, preventing the onset of ovulation and the penetration of active sperm into the uterine cavity.

Regulon is considered an effective oral contraceptive and is used as a means of preventing unwanted pregnancy. Also, the drug is used in order to normalize the menstrual cycle and the treatment of dysfunctional uterine bleeding.

Clinico-pharmacological group

Monophasic oral contraceptive.

Terms of sale from pharmacies

You can buy by prescription.


How much is Regulon in pharmacies? The average price is at the level of 500 rubles.

Composition and release form

Regulon dosage form of release - film-coated tablets: almost white or white, biconvex, round, on one side “P8” marking, on the other - “RG” (21 pieces in blisters, in a cardboard bundle 1 or 3 blisters ).

Active substances in the composition of 1 tablet:

  • Desogestrel - 0.15 mg;
  • Ethinyl estradiol - 0.03 mg.

Additional components: magnesium stearate, α-tocopherol, lactose monohydrate, stearic acid, colloidal silicon dioxide, potato starch, povidone.

Film coating: propylene glycol, hypromellose, macrogol 6000.

Pharmachologic effect

Regulon tablets due to their constituent active ingredients (ethinyl estradiol is an analogue of estrogen, and desogestrel - progesterone) have a contraceptive effect. They inhibit the synthesis of gonadotropin hormones, the process of ovulation (the release of a mature egg). In addition, the active ingredients impede the movement of sperm in the cervical canal due to thickening of the cervical mucus and alter the epithelium of the endometrium (inner layer of the uterus wall), which prevents the implantation process (attachment of a fertilized egg).

Also, the drug has a beneficial effect on the lipid (fat) metabolism of the female body, increasing the concentration of high-density lipoproteins, normalizes the menstrual cycle, reduces the intensity of menstrual bleeding.

Indications for use

Regulon is used to prevent unwanted pregnancy.



  1. Dyslipidemia;
  2. Gallstone disease currently or in history;
  3. Pregnancy (including suspect);
  4. Breastfeeding period;
  5. Smoking over the age of 35 (more than 15 cigarettes per day);
  6. Thrombosis (arterial or venous) or thromboembolism at present or in history, including deep vein thrombosis of the leg, stroke, myocardial infarction, pulmonary embolism;
  7. Severe liver damage, hepatitis (including history), cholestatic jaundice, including developed during a previous pregnancy, (before normalization of laboratory and functional parameters and for three months after their return to normal);
  8. Jaundice caused by taking glucocorticoids (drugs containing steroid hormones);
  9. Liver tumors (incl. History);
  10. Syndromes Dubin-Johnson, Gilbert, Rotor;
  11. Malignant hormone-dependent neoplasms of the mammary glands and genitals (diagnosed or suspected);
  12. Severe itching, otosclerosis, or aggravation of it when taking glucocorticosteroids or during a previous pregnancy;
  13. Vaginal bleeding of obscure nature;
  14. Explicit and / or multiple risk factors for venous or arterial thrombosis (including mild or severe arterial hypertension with blood pressure readings ≥ 160/100 mm Hg);
  15. Thrombosis precursors (including angina pectoris, transient ischemic attack) including history data;
  16. Venous thromboembolism in relatives;
  17. Migraine, accompanied by focal neurological symptoms (including indications in history);
  18. Pancreatitis, occurring with severe hypertriglyceridemia (including in history);
  19. Diabetes mellitus complicated by angiopathy;
  20. Hypersensitivity to the components of the tool.

Relative (required to be used with extreme caution due to the high risk of arterial or venous thrombosis / thromboembolism):

  1. Epilepsy;
  2. Migraine;
  3. Obesity (body mass index more than 30 kg / m²);
  4. Age over 35 years;
  5. Arterial hypertension;
  6. Family history;
  7. Dyslipoproteinemia;
  8. Valvular heart disease, atrial fibrillation;
  9. Postpartum period;
  10. Ulcerative colitis, Crohn's disease;
  11. Sickle cell anemia;
  12. Acute and chronic liver disease;
  13. Hypertriglyceridemia (including family history instructions);
  14. Extensive surgery, surgery on the lower limbs;
  15. Prolonged immobilization;
  16. Severe injury;
  17. Varicose veins and superficial thrombophlebitis;
  18. Depression in the severe form (including data in the anamnesis);
  19. Diabetes without vascular disorders;
  20. Changes in biochemical parameters (protein C or S deficiency, resistance of activated protein C, antithrombin III deficiency, hyperhomocysteinemia, antiphospholipid antibodies, including antibodies to cardiolipin, lupus anticoagulant);
  21. Systemic lupus erythematosus (SLE).

Appointment during pregnancy and lactation

Pregnancy is an absolute contraindication to the appointment of Regulon. During lactation, you should refuse to take the drug or stop breastfeeding.

This is due to the fact that taking the pills in the postpartum period causes a decrease in the amount of milk, worsens lactation and adversely affects the growth of the child.

Pregnancy after birth control pills Regulon

The contraceptive effect of Regulon tablets is associated with the ability of its constituent synthetic analogs of endogenous hormones estradiol and progestogens to prevent the release of a mature egg from the follicle.

As a means of contraception, the drug may be used for several years. However, many women are worried about whether this will somehow affect the reproductive function and subsequent pregnancy.

Gynecologists answer these questions like this: if you take the pills correctly (that is, take it according to the scheme described in the instructions and in compliance with all the recommendations of your doctor), then upon completion of their admission you can plan the pregnancy. Usually, pregnancy after Regulon occurs after about 6 months of active sex life.

A woman who plans a child, doctors recommend to stop taking the drug at least three months before conception.

Dosage and method of use

As indicated in the instructions for use Regulon is prescribed inside.

Taking pills start from the 1st day of the menstrual cycle. Assign 1 tab./day for 21 days, if possible at the same time of day. After taking the last pill from the package, a 7-day break is taken during which menstrual-like bleeding occurs due to discontinuation of the drug. The next day after a 7-day break (4 weeks after taking the first pill, on the same day of the week), taking the drug from the next package, which also contains 21 tabs, is resumed, even if the bleeding has not stopped. This pill regimen is followed as long as there is a need for contraception. When complying with the admission rules, the contraceptive effect is maintained for the duration of the 7-day break.

The first dose of the drug:

  • The first pill should be taken from the first day of the menstrual cycle. In this case, you do not need to use additional methods of contraception. Taking the pills can be started from 2-5 days of menstruation, but in this case, in the first cycle of using the drug, additional methods of contraception should be used in the first 7 days of taking the pills. If more than 5 days have passed after the onset of menstruation, you should postpone the start of the drug until the next menstruation.

Taking the drug after abortion:

  • After an abortion, in the absence of contraindications, it is necessary to begin taking pills from the first day after the operation, and in this case there is no need to use additional methods of contraception.

Taking the drug after childbirth:

  • Non-breastfeeding women can start taking pills no earlier than 21 days after delivery, after consulting a doctor. In this case, there is no need to use other methods of contraception. If after childbirth there was already sexual contact, then pills should be postponed until the first menstruation. If you decide to take the drug later than 21 days after delivery, then in the first 7 days you need to use additional methods of contraception.

Transfer from another oral contraceptive:

  • When switching from another oral drug (21 or 28 days old): the first tablet of Regulon is recommended to be taken the next day after completing the course of the 28-day package of the drug. After completing the 21-day course, you need to take a regular 7-day break and then start taking Regulon. No need to use additional methods of contraception.

Transition to Regulon after using oral hormone preparations containing only progestogen (“mini-pili”):

  • The first tablet Regulon should be taken on the 1st day of the cycle. No need to use additional methods of contraception. If menstruation does not occur when taking a mini-drink, after excluding pregnancy, you can start taking Regulon on any day of the cycle, but in this case, additional contraceptive methods should be used in the first 7 days (using a cervical cap with a spermicidal gel, a condom, or abstinence from sexual intercourse). The use of the calendar method in these cases is not recommended.

Postponement of the menstrual cycle:

  • If there is a need to postpone menstruation, it is necessary to continue taking pills from a new package, without a 7-day break, in the usual way. With the postponement of menstruation, breakthrough or spot bleeding may appear, but this does not reduce the contraceptive effect of the drug. Regulon's regular intake can be restored after the usual 7-day break.

Vomiting / diarrhea:

  • If after taking the drug appears vomiting or diarrhea, then the absorption of the drug may be defective. If the symptoms stopped within 12 hours, then you need to take another pill extra. After that, you should continue taking the pills in the usual way. If vomiting or diarrhea continues for more than 12 hours, then additional contraceptive methods should be used during vomiting or diarrhea and for the next 7 days.

Missed pills

If a woman forgot to take a pill in a timely manner, and after skipping no more than 12 hours have passed, you need to take a forgotten pill, and then continue taking it at your usual time. If more than 12 hours have passed between taking the pills, this is considered to be skipping the pill, the contraceptive reliability in this cycle is not guaranteed and the use of additional methods of contraception is recommended.

When skipping one pill in the first or second week of the cycle, you need to take 2 tab. the next day and then continue regular intake, using additional contraceptive methods until the end of the cycle.

When you skip a pill in the third week of the cycle, you must take a forgotten pill, continue taking it regularly and not take a 7-day break. It is important to remember that due to the minimal dose of estrogen, the risk of ovulation and / or bleeding increases when you skip a pill and therefore it is recommended to use additional contraceptive methods.

Side effect

Regulon may cause the following side effects:

  1. On the part of the senses: partial hearing loss associated with otosclerosis.
  2. Others: Sydenham chorea, hemolytic-uremic syndrome, porphyria.
  3. On the part of the cardiovascular system: arterial or venous thromboembolism, arterial hypertension.

More rare side effects:

  1. From the side of the central nervous system: headaches, frequent mood swings, depression.
  2. Dermatological reactions: rash, nodal or exudative erythema.
  3. On the part of the organs of vision: the sensitivity of the cornea when wearing contact lenses.
  4. On the part of the metabolism: stagnant fluids in the body, weight gain or decrease in tolerance to carbohydrates.
  5. On the part of the digestive system: nausea, ulcerative colitis, vomiting, Crohn's disease, cholestasis, the occurrence or exacerbation of jaundice.
  6. On the part of the reproductive system: inflammation of the vagina, an increase in the mammary glands or soreness in them, acyclic hemorrhages from the vagina, galactorrhea, candidiasis.
  7. Other: allergic reactions.


In case of exceeding the recommended therapeutic dose of Regulon tablets, nausea and vomiting may develop, young women will develop bloody discharge from the vagina. The treatment consists in washing the stomach, if no more than 3 hours have passed since the overdose, bowels, taking sorbents (activated carbon), carrying out symptomatic therapy in the conditions of a medical hospital.

Special instructions

It is not recommended to start taking the drug without consulting a gynecologist, since Regulon can be used only as prescribed by a doctor based on the results of a preliminary general medical and gynecological examination. The physician should examine in detail both the general condition of the woman (family and personal history, laboratory tests, blood pressure), and the results of examination of the pelvic organs, mammary glands, cytological analysis of cervical smear. The decision about hormonal oral contraceptive therapy should be weighed, taking into account all the benefits and negative effects.

A woman should be warned about the need for regular (1 every 6 months) preventive examinations during the period of taking the pills. With the appearance or worsening of diseases of the hemostatic system, deviations in laboratory parameters of liver function, signs of development of renal and / or cardiovascular insufficiency, migraine, epilepsy, not complicated by vascular disorders of diabetes mellitus, severe depression, estrogen-dependent tumors or gynecological diseases, sickle cell anemia taking the drug must be discontinued and use non-hormonal methods of contraception.

The risk of thromboembolic diseases in patients receiving hormonal contraceptives exists, but it is not higher than during pregnancy. In rare cases, arterial or venous thromboembolism of retinal vessels or renal, hepatic, mesenteric vessels may appear. Their probability increases in women with heavy smoking, age over 35, obesity, hypertension complicated with hemodynamic disturbances pathologies of the heart valves, atrial fibrillation, dislipoproteinemia, prolonged immobilization, complicated by vascular lesions of diabetes, as well as the presence of thromboembolic diseases in the family history ( parents, sister, brother).

Before a planned operation on the lower extremities or extensive surgical intervention, the drug should be temporarily stopped and resumed after remobilization after 2 weeks.

Symptoms of thromboembolism include sudden chest pain radiating to the left arm, shortness of breath, severe headache, accompanied by diplopia, partial or complete sudden loss of vision, dizziness, aphasia, collapse, weakness, severe numbness of half of the body, focal epilepsy, acute stomach, impaired motility function, expressed unilateral pain in the gastrocnemius muscle.

Women prone to chloasma should avoid exposure to direct sunlight and ultraviolet radiation.

The effectiveness of the drug may violate concomitant therapy with other drugs, in this case, the use of additional barrier methods of contraception is required.

If there are acyclic bleeding or no menstrual bleeding after regular use of two blister tablets, take the pill and examine it to rule out pregnancy.

Estrogenic components of oral contraceptives can influence the level of laboratory parameters of the functional parameters of the thyroid gland, kidneys, adrenal glands, hemostasis, liver, the content of transport proteins and lipoproteins.

The use of Regulon in women with menorrhagia significantly reduces menstrual blood loss, normalizes the menstrual cycle, has a beneficial effect on the condition of the skin, especially with acne vulgaris.

In severe pathologies of the liver, hepatitis, cholestatic jaundice, drug administration is possible only 3 months after recovery and preservation of normal laboratory and functional parameters.

The drug does not protect against sexually transmitted diseases, including HIV infection (AIDS).

Taking pills does not affect a woman's ability to drive and other mechanisms.

Interaction with other drugs

Drugs that induce hepatic enzymes, such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, and St. John's wort, reduce the effectiveness of oral contraceptives and increase the risk of breakthrough inhaler. The maximum level of induction is usually achieved not earlier than 2-3 weeks, but can last up to 4 weeks after discontinuation of the drug.

Ampicillin and tetracycline reduce the effectiveness of Regulon (interaction mechanism is not established). If necessary, the joint reception is recommended to use an additional barrier method of contraception during the entire course of treatment and for 7 days (for rifampicin - within 28 days) after discontinuation of the drug.

Oral contraceptives can reduce carbohydrate tolerance, increase the need for insulin or oral antidiabetic agents.


We offer you to read the reviews of people who used the drug Regulon:

  1. Dasha. She took “Regulon” as a contraceptive, the first course of treatment was 6 months. There were no problems. Yes, and then the price pleased. Unlike similar drugs, the price was lower at more than half the cost. The drug has coped with its goal - there was no pregnancy, the cycle was normal, acne was gone, the hair stopped falling out. But a couple of years later she faced a cycle violation, the doctor again prescribed this drug, bearing in mind past positive experiences. But alas, this time to a significant increase in weight (5.2 kg per month intake), swelling of the legs, arrhythmia of the heart and nausea after taking were added. But the hair and skin really shone. After two months of administration, the drug had to be replaced with a similar one, and all the symptoms disappeared immediately. No longer risk taking it.
  2. Nastya. I did not dare to take this regullon as a contraceptive, to be honest, I was afraid. My friend took him about 2 years ago not to get pregnant, but she does not say anything good about him. On the contrary, she claims to have gained a lot of weight. Therefore, I did not dare, in any case, it is up to you to decide and go to consult with the gynecologist.
  3. Oksana. When the question of contraception arose after the birth of my daughter, I, while breastfeeding, used spermicidal suppositories and creams. When breastfeeding stopped, she decided to switch to pills. What to say? “Regulon” copes with its mission as “excellent”. The cost of the pills is quite affordable. From the heap of side effects described in the instructions, I did not feel anything like that. Menstruation came in day to day, of moderate profusion and without pain. Even the migraines that tormented me before the CD passed. By the way, I drank Regulon a few years before pregnancy, and then I managed to get pregnant and give birth to a healthy child safely, plannedly and fairly quickly.


Structural analogues of the active substance:

  • Marvelon;
  • Mersilon;
  • Novinet;
  • Three Merci.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Tablets should be stored in a dry place at a temperature of 15 ° to 30 ° C.

Regulon's shelf life is 3 years.

Watch the video: Sergio Reguilón 2019 Overall Skills - Real Madrid (January 2020).


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