Ortofen - a medical tool used in various diseases of the musculoskeletal system. In addition to anti-inflammatory and analgesic effects, it also has a slight antipyretic effect.

Penetrates into the blood plasma and synovial fluid of the joints, where it has its effect. Diclofenac, which is a part of it, is today the "gold standard" for the treatment of diseases and injuries of the musculoskeletal system.

This status of this medication is explained not only by its rapid analgesic and anti-inflammatory action, but also by the results of research proving its relative safety compared with other NSAIDs representatives.

Used to treat rheumatoid and certain types of reactive arthritis and other diseases of the osteo-articular system, as well as the effects of injuries.

Clinico-pharmacological group

NSAID, a derivative of phenylacetic acid.

Pharmacy sales terms

Tablets and ointment are sold without a doctor's prescription.


How much does Ortofen in pharmacies? The average price is at 50 rubles.

Release form and composition

Ortofen release in several dosage forms, namely:

  • In tablets of 25 mg.
  • In the form of ointment or gel 2%, for external use.
  • In the form of an ampoule solution for intramuscular administration.

The active ingredient of Ortofen is diclofenac sodium:

  • 1 tablet: 0.025 g;
  • 1 ml of solution: 0.025 g;
  • 1 g ointment: 0.02 g;
  • 1 g of gel: 0.05 g

Auxiliary components of the gel: propylene glycol, ethanol 95%, gietelloza, purified water.

Pharmacological effect

Ortofen is indicated for the treatment of various diseases of the musculoskeletal system. The mechanism of action is based on the inhibition of the production of substances that cause inflammation and pain. The advantage of the drug is that it acts at the cellular level, inhibiting the synthesis of the enzyme (COX-1), which is responsible for the production of inflammatory mediators.

As with osteochondrosis, and with many degenerative diseases of the joints, a powerful inflammatory process develops due to the destruction of cartilage tissue, which leads to pain. The use of Ortofen is indicated for such painful conditions, as it blocks the development of inflammation, thereby reducing pain.

Indications for use

On the attached instructions to Ortofen, the use of the drug is indicated for the symptomatic treatment of degenerative and inflammatory lesions of the musculoskeletal system:

  • Gout;
  • Osteoarthrosis;
  • Arthritis - juvenile chronic, rheumatoid, psoriatic;
  • Osteoarthritis;
  • Ankylosing spondylitis;
  • Periarthropathy.

Ortofen is also recommended for reducing or relieving pain in the background:

  • Neuralgia;
  • Algomenorrhea;
  • Toothache;
  • Radiculitis;
  • Sciatica;
  • Myalgia;
  • Ossalgii;
  • Headaches (migraines);
  • Lumbago;
  • Tendovaginitis;
  • Arthralgia;
  • Proctitis;
  • Adnexitis;
  • Renal and biliary colic.

Ortofen is prescribed, according to the instructions, also to reduce pain in case of: postoperative and post-traumatic lesions (sprains, sprains, bruises); combined treatment of infectious diseases of upper respiratory tract: otitis, tonsillitis, pharyngitis; excessive physical exertion that caused muscle and joint pain.

In ophthalmic practice, the drug is used for:

  • Therapy for non-infectious conjunctivitis;
  • Cataract surgery to inhibit miosis;
  • Post-traumatic inflammation in injuries of the eyeball.

And also to prevent cystoid macular edema during removal and implantation of the lens.


Ortofen is not used for "aspirin" asthma, for diclofenac intolerance, for a variety of disorders of the blood coagulation system, for hematopoietic disorders, for the "aspirin" triad (recurrent nasal polyposis, paranasal sinuses combined with bronchial asthma and intolerance of the sylvic), we are in the body, and we are not satisfied with the aspirin triad; during pregnancy, erosive and ulcerative lesions in the digestive tract, with hemophilia, breastfeeding, anemia, leukopenia, bleeding tendency, prolongation of the period bleeding, children under 6 years of age.

Edema, alcoholism, renal and hepatic failure, arterial hypertension, erosive and ulcerative lesions of the digestive system, decompensated form of chronic heart failure, anemia, bronchial asthma, diabetes mellitus, in the postoperative period, with acute induced porphyria and elderly patients, in a postoperative period, with adult induced porphyria and elderly patients, in a post-operative period, with adult induced porphyria and elderly patients, in the elderly, in a post-operative period, with adult induced porphyria and patients, the adult has a mature adult. prescribed with caution.

Use during pregnancy and lactation

Use during pregnancy and lactation is possible only if the intended benefit to the mother outweighs the potential risk to the fetus or child.

Dosage and method of use

The instructions for use indicate that the exact dose of Ortofen installed individually.

  • In tablets, adults are usually prescribed 25-50 mg 2-3 times a day. The highest permissible daily dose is 150 mg. Take the tablets should be on an empty stomach, swallowing whole, squeezed with a sufficient amount of water.
  • In the form of a solution, the drug is usually used to treat acute conditions and relieve exacerbations of the chronic process — 75 mg each as a single intramuscular injection (deep into the gluteus maximus muscle). Next, the patient is transferred to Ortofen tablets.

Children determine the dose depending on their weight - 2 mg per kilogram of body weight.

  • In the form of an ointment and a gel, the drug is applied to the affected area of ​​2-4 g 3-4 times a day.

The duration of treatment in each case is determined individually for each patient depending on the indications, the dosage form of the drug used and the effectiveness of the therapy.

Side effects

The use of Ortofen may be accompanied by side effects that affect almost all body systems:

  1. Kidneys: edema, proteinuria, renal failure, nephritis, medullary necrosis, etc.
  2. Gastrointestinal tract: nausea, diarrhea, constipation, vomiting, erosive gastritis, peptic ulcer, melena and GCC, glossitis, pancreatitis, etc.
  3. Liver and biliary tract: jaundice, liver failure, hepatitis, increased levels of liver enzymes, etc.
  4. Heart: chest pain, high blood pressure, heartbeat, heart attack, etc.
  5. CNS: dizziness, sleep disturbance, tinnitus, blurred vision, headache, taste distortion, memory impairment, acute disturbance of cerebral blood circulation.
  6. Other side effects: asthma, anemia, depression, impotence, post-injection abscess.

Complications of the treatment of the digestive system (NSAID-gastropathy) are most often observed, but it should be noted that, according to the doctors, most of the above side effects of Ortofen are extremely rare.

Ointment for external use of 2%, gel for external use of 5%

  • Rarely: burning, itching, rash, redness;
  • Possible: with prolonged use and / or application to large areas of the body - the appearance of systemic side effects against the background of the resorptive effect of diclofenac.


Information about cases of overdose when applying the cream no.

Tableted form: non-specific symptoms of poisoning, like vomiting (and how dangerous it is when poisoning, read the article Vomiting with blood), gastric bleeding, diarrhea, dizziness, tinnitus, loss of consciousness and convulsions.

There is no specific antidote. The patient is prescribed symptomatic treatment, which includes the intake of enterosorbents, alkaline drinking and means that cause forced diuresis (artificial stimulation of urine output). In parallel, the correction of disorders of the gastrointestinal tract, as well as special measures to eliminate hypertension, seizures and respiratory depression.

Special instructions

Before you start using the drug, read the specific instructions:

  1. Not recommended for use in children under 6 years.
  2. During treatment with dosage forms for systemic use, alcohol is not recommended.
  3. It is used with extreme caution in cases of liver, kidney, gastrointestinal tract history, dyspeptic symptoms, bronchial asthma, hypertension, heart failure, immediately after serious surgical interventions, as well as in elderly patients.
  4. Rectal administration is not recommended in patients with a history of anorectal disease or anorectal bleeding. Externally, should be used only on intact skin.
  5. For indications of a history of allergic reactions to NSAIDs and diclofenac sulphites, they are used only in emergency cases. In the process of treatment requires systematic monitoring of liver and kidney function, peripheral blood pictures.
  6. Diclofenac should be avoided in the eyes (with the exception of eye drops) or on the mucous membranes. Patients using contact lenses should use eye drops no earlier than 5 minutes after removing the lenses.

During the period of treatment may decrease the speed of psychomotor reactions. If visual clarity deteriorates after using eye drops, you should not drive a car or engage in other potentially dangerous activities.

Drug interactions

When using the drug, you must consider the interaction with other drugs:

  1. Antibacterial derivatives of quinolone - there are separate reports on the development of seizures in patients who received both quinolone derivatives and diclofacac.
  2. NSAIDs and GCS - with simultaneous systemic use of diclofenac and other systemic NSAIDs or GCS may increase the incidence of adverse events (in particular, from the gastrointestinal tract).
  3. Anticoagulants and antiplatelet agents - an increased risk of bleeding cannot be ruled out with simultaneous use of diclofenac and with drugs of these groups.
  4. Selective serotonin reuptake inhibitors - may increase the risk of gastrointestinal bleeding.
  5. Hypoglycemic drugs - cases of both hypoglycemia and hyperglycemia cannot be excluded, which necessitated a change in the dose of hypoglycemic drugs during the use of diclofenac.
  6. Potent inhibitors of CYP2C9 - with co-administration of diclofenac and potent inhibitors of CYP2C9 (such as voriconazole), an increase in serum diclofenac concentration and an increase in systemic action caused by inhibition of diclofenac metabolism is possible.
  7. Lithium, digoxin - may increase the concentration of lithium and digoxin in the plasma Krivi. It is recommended to monitor the concentration of lithium, digoxin in the blood serum.
  8. Diuretic and antihypertensive drugs - when used simultaneously with diuretics and antihypertensive drugs (for example, beta-blockers, ACE inhibitors), diclofenac may reduce their hypotensive effect.
  9. Cyclosporine - The effect of diclofenac on kidney prostatglandin activity may enhance cyclosporine nephrotoxicity.
  10. Drugs that can cause hyperkalemia - combined use of diclofenac with potassium-saving diuretics, cyclosporine, tacrolimus and trimethoprim can lead to an increase in plasma potassium levels (this indicator should often be monitored for this combination).
  11. Methotrexate - when using diclofenac within 24 hours before or within 24 hours after taking methotrexate, it is possible to increase the concentration of methotrexate in the blood and enhance its toxic effect.
  12. Phenytoin - may increase the action of phenytoin.


We picked up some reviews of people using the drug Ortofen:

  1. Vera. I helped, the second day I drink and severe pain in my knee subsided. In the morning and evening, 2 tablets. Only take after meals so as not to have a stomach ache.
  2. Victor. I got a side effect from him, my stomach started to hurt badly, my stomach twisted. but pain Ortofen really removed. But one thing ceased to hurt, another began ((
  3. Alina. My husband is very much and often hurt the joints. He used to smear with ointments different: both expensive and cheap. Everything had a temporary effect. And once in a pharmacy he was offered ortofen for joint pain. The medicine helped immediately. Understandably - it is after all. We were told that we needed to drink a course - 3 weeks, then take a break and take it only for pain. With severe pain after a couple of months, the course of taking the drug should be repeated. After three weeks of taking the medicine, the pain went away and then appeared less frequently. I would also like to note that the price of ortofen is rather low, which makes it affordable for everyone.
  4. Lydia Good drug. Quickly relieves joint pain. But by the way ... Not only did she take a stomach ache all the time, but the gastroenterologist also prohibited her from taking it when she asked for indigestion in the stomach. He said that there are erosion and such a plan drugs with diclofenac banned. I had to put ortofen aside and learn to live with pain in my knees. So I live 🙁


In the pharmaceutical market of our state there is a huge selection of Ortofen analogues (list):

  • Diklak,
  • Voltaren,
  • Dicloran,
  • Diclogen,
  • Sanfinak,
  • Diclomax,
  • Diclofenac,
  • Naklofen,
  • Orthofer,
  • Feloran,
  • Dikloberl,
  • Revmavek.

Before using analogues consult your doctor.

Storage conditions and shelf life

Store in a dry, protected from light, out of reach of children, at a temperature of 15-25 C. Storage life is 3 years. After the expiration date of the drug is not suitable for use.

Watch the video: Ortofen diklofenak RUS. Ортофлекс. Grindeks (January 2020).


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