Injections Diclofenac is a drug designed to relieve pain and consists of para-hydroxybenzoic acid (NSAIDs), phenylacetic derivatives, not related to the steroid group of anelgetikov.
Causes a protective and adaptive response of the body, aimed at eliminating the effects of pathogenic stimuli and restoring the function of damaged organs. It has a clear chemotherapeutic property regarding diseases of local tissue damage. It is a non-selective inhibitor of the enzyme cyclooxygenase, which increases the sensitivity of nociceptive receptors to pain mediators.
On this page you will find all the information about Diclofenac: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Diclofenac injections. Want to leave your opinion? Please write in the comments.
NSAID, a derivative of phenylacetic acid.
Pharmacy sales terms
It is released on prescription.
How much are Diclofenac ampoules? The average price in pharmacies is at 36 rubles.
Release form and composition
For ease of use, Diclofenac is available in a wide variety of dosage forms:
- enteric coated tablets (25.50 mg);
- prolonged action capsules (100mg);
- rectal candles (50 and 100 mg);
- Diclofenac ointment (1% and 2%);
- Diclofenac gel (1% and 5%);
- Diclofenac injections in ampoules for intramuscular administration;
- eye drops (0.1%).
Diclofenac tablet forms, as well as injections, are very good for rheumatic joints and diseases accompanied by severe pain. Local remedies in the form of a gel and ointment are used for the external treatment of foci of inflammation in order to eliminate puffiness and painful sensations. Diclofenac eye drops are prescribed for the treatment of post-traumatic conditions.
Diclofenac shots have the following effects:
The explanation of the effectiveness of the active substance is the inhibitory effect on cyclooxygenase. In connection with it, the formation of prostaglandins is inhibited. Also, the drug inhibits platelet aggregation reactions. Diclofenac eliminates soreness, stiffness of joints, restores their functionality. If necessary, use in cases of post-traumatic and postoperative complications helps to alleviate both spontaneous pain syndrome and pain during movement.
Indications for use
What helps? The appointment of diclofenac is justified in the following cases:
- ankylosing spondylitis (ankylosing spondylitis);
- injuries of the musculoskeletal system;
- autoimmune diseases of the connective tissue;
- postoperative pain;
- inflammation of the joints and muscles, accompanied by pain;
- rheumatism, including conditions that are accompanied by simultaneous damage to the organs of the musculoskeletal system;
- degenerative-dystrophic diseases of the organs of motion - arthrosis, osteoarthrosis, osteochondrosis of the spine;
- neuralgia, which are accompanied by severe pain.
Diclofenac solution is contraindicated in the following conditions:
- violations of the blood;
- changes in hemostasis, including hemophilia;
- exacerbation of gastrointestinal lesions (erosive and ulcerative);
- bleeding from the digestive tract;
- children up to 18 years;
- "Aspirin Triad" - intolerance to NSAIDs in patients with bronchial asthma and nasal polyps;
- with intolerance of the main or auxiliary in-in, as well as in the presence of hypersensitivity to other NSAIDs.
It is prescribed with caution in the following conditions: bronchial asthma, anemia, congestive heart failure, edematous syndrome, arterial hypertension, hepatic or renal failure, inflammatory bowel disease, alcoholism, erosive-ulcerative gastrointestinal diseases chronic (without exacerbation), diabetes, diverticulitis, induced porphyria , condition after serious surgical interventions, old age, systemic pathologies of connective tissue.
Use during pregnancy and lactation
The use of Diclofenac is possible in 1 and 2 trimesters of pregnancy strictly according to indications and after a doctor's prescription! The drug affects the development of the embryo and increases the risk of congenital malformations. Diclofenac is prescribed in a minimum amount and for a short period.
In the 3rd trimester of pregnancy, the use of the drug can lead to severe hypoxia and fetal death. In addition, Diclofenac reduces the contractility of the uterus, which is fraught with weakness of labor and postpartum hemorrhage.
Instructions for use
The instructions for use indicated that the appointment of diclofenac injections provides for a technique of its introduction. So, everyone who will inject it intramuscularly should be aware that the solution of this drug should be injected deep into the gluteus muscle, into the upper extreme part (upper outer quadrant of the buttock).
Injections should be alternated alternately in one, then in another buttock. It is recommended to inject diclofenac injections warmed to body temperature. To do this, the ampoule with the medicine should be warmed, holding it in the palm of your hand. Such heating will make the introduction of the drug more comfortable, will contribute to a more rapid action of the active components of the drug and will allow more rapid numbing of the patient.
- The recommended therapeutic dose of the drug is 75 mg (1 ampoule per day). The course of treatment should not last more than 2 days, if necessary, then proceed to oral or rectal use of the medication.
- In severe forms of the disease (for example, with colic), two injections of 75 mg each can be given, with an interval of several hours (the second injection should be carried out in the opposite gluteal region).
- Alternative: intramuscular administration of the drug 1 time per day (75 mg) can be combined with taking diclofenac in other dosage forms (tablets, rectal suppositories), while the total daily dose should not exceed 150 mg.
- For attacks of migraine: intramuscularly in a dose of 75 mg (at the very beginning of the attack), if necessary, suppositories can be added on the same day in a dose of up to 100 mg. The total daily dose should not exceed 175 mg.
For diseases of the cardiovascular system (including those with uncontrolled arterial hypertension) or high risk of developing cardiovascular diseases, Diclofenac should be used with extreme caution. If the course of treatment lasts more than 4 weeks, the drug should be used in a daily dose not exceeding 100 mg.
Side effects of Diclofenac injections can be divided into groups, as presented in the table below.
|Organ system or group of symptoms||Side effects|
|Infectious pathologies||In rare situations, a post-injection abscess is likely to develop if the rule of skin disinfection is not followed before the injection.|
|Hematopoietic system||Leukopenia and agranulocytosis, thrombocytopenia, aplastic and hemolytic variants of anemia.|
|Immunity system||Hypersensitivity, including anaphylactic shock, angioedema.|
|Nervous system||Headaches and dizziness, worsening of sleep, memory, sensory disturbances, convulsive states, aseptic form of meningitis, strokes.|
|Mental Disorders||Unreasonable attacks of anxiety, irritability, depressions, nightmares, disorientation in space.|
|Visual Analyzer||Diplopia, blurred vision.|
|Auditory analyzer||Tinnitus, hearing impairment.|
|The cardiovascular system||Arrhythmias, heart failure symptoms, myocardial infarction, pain syndrome, increase in blood pressure, vasculitis.|
|Respiratory system||Bronchial asthma, pneumonitis.|
|Gastrointestinal tract||Abdominal pain, vomiting and nausea, impaired digestion, bloating, diarrhea, gastritis, peptic ulcer, gastrointestinal bleeding. The rare negative consequences of the gastrointestinal tract include glossitis and stomatitis, dysgeusia (taste disorder), the formation of intestinal diaphragm-like structures, colitis, pancreatitis, and constipation.|
|Liver and biliary tract||Hepatitis, deterioration of the functional state of the liver, a jump in the activity of enzymes-transaminases in the blood.|
|Dermatological pathology||Rash, dermatitis, erythema, eczema, Lyell and Stevens-Johnson syndromes, purpura, alopecia, photosensitivity.|
|Excretory system||Nephrotic syndrome, nephritis, proteinuria and hematuria, poor kidney function.|
|Common symptoms||Soreness and the formation of a seal at the site of administration of the drug, less often - swelling and necrotic changes at the injection site.|
With a slight excess of the specified daily allowable dose, the patient may experience the following symptoms:
- nausea, vomiting, dizziness, up to loss of consciousness;
- epigastric pain.
In the presence of an overdose, symptomatic treatment is carried out, which means:
- Washing the digestive tract, reducing the concentration of toxins;
- The introduction of a large dose of any sorbent that binds and neutralizes toxins.
- Drink plenty of boiled water at room temperature.
Before using Diclofenac, it is important to familiarize yourself with its instructions. It is necessary to pay attention to a number of special instructions, which include:
- With the simultaneous use of other nonsteroidal anti-inflammatory drugs, the dose of Diclofenac injection solution must be reduced.
- The active ingredient of the drug inhibits the aggregation (gluing) of platelets, so during the use of the solution for parenteral administration of Diclofenac, it is necessary to carry out laboratory monitoring of the state of the hemostatic system (blood coagulation system).
- During the course of treatment of the drug is not recommended to perform work requiring increased concentration or speed of psychomotor reactions.
Simultaneous use with:
- GCS or other NSAIDs - causes adverse reactions from the gastrointestinal tract;
- cyclosporine - increases nephrotoxic effect of the latter;
- antidiabetic drugs - may trigger hyper- or hypoglycemia;
- methotrexate - can lead to increased concentrations and increased toxicity of the latter;
- antihypertensive drugs and diuretics - reduces the effectiveness of these funds;
- acetylsalicylic acid - helps to reduce the serum concentration of diclofenac;
- potassium-sparing diuretics - leads to hyperkalemia;
- anticoagulants - requires regular monitoring of hemocoagulation;
- lithium preparations, phenytoin or digoxin - helps to increase the plasma concentration of these funds.
If there is evidence, eye drops can be combined with other ophthalmologic agents that include GCS (between instillations it is necessary to withstand at least a 5-minute break).
Consequences of alcohol with NSAIDs
Drinking alcohol during the period of NSAID treatment may cause:
- development of unpredictable complications and adverse reactions;
- deterioration of the liver;
- reduce the effectiveness of the drug;
- hypertension and, as a result, increased stagnation in the circulatory system and intoxication of the body.
Injections and alcohol compatibility do not have, since the injection form of the drug stimulates the activity of the central nervous system, and alcohol, by contrast, inhibits it. As a result, quite serious neurological disorders are possible.
We picked up some reviews of people about Diclofenac injections:
- Sergei. I have two intervertebral hernias constantly pricking diclofenac. I always hear from doctors that he is harmful, they are trying not to prescribe him. What is harmful is not explained. I tried various painkillers, and expensive ones as well. I do not know why, but only diclofenac acts on me. The price is generally ridiculous 55 rubles.
- Anna. Although my diclofenac was pricked in my injections, my stomach began to hurt a lot. So the most interesting thing is, then in a paid clinic they said that it wasn’t necessary to install it at all, but it was necessary to put an elbon, because it heals joints, and diclofenac just relieves inflammation.
- Alexander. My acquaintance with dikolfenak took place because of one unexpected incident. It was necessary to meet the niece early in the morning. He got up early, began to dress, but did not manage to pull on the second leg of his trousers, as the wildest pain pierced. Sweat rolled in hail, but somehow got dressed, his wife helped get behind the wheel, met. And in the morning in the clinic, diagnosis, osteochondrosis. They prescribed diclofinac injections, and although it is often about notorious fame, it was he who helped me on the new day at least to serve myself. Perhaps a lot of side effects, but nevertheless still with his task, he copes great.
- Oksana. I have long suffered from such an unpleasant disease as gonarthrosis. Exacerbations occur regularly, 2-3 times a year, especially in the wet, spring-autumn period. At this time I suffer from painful pain in the joints. During the next exacerbation, the rheumatologist prescribed Diclofenac. The drug is quite inexpensive, the pharmacy is released freely. So, I felt relief on the second day after the start of treatment. The course took only 5 days. But the doctor warned that a second course can be taken no earlier than six months, since Diclofenac can provoke a stomach ulcer with frequent use.
Most practitioners speak about Diclofenac as an effective and fast-acting medication. Meanwhile, the cardiovascular risk of diclofenac is higher than that of its other "relatives" from the NSAID group. The shorter the course of treatment, the less likely the development of negative side effects. It is extremely important to observe the recommended dosage, take into account contraindications and not resort to self-treatment without a doctor's prescription.
If for any reason the pharmacy did not have Diclofenac or the patient has contraindications, such a drug can be replaced with a similar remedy.
Analogues of diclofenac are:
Before using analogues consult your doctor.
Which is better: Diclofenac or Ibuprofen?
Ibuprofen-based drugs indiscriminately inhibit COX. That is, having the same indications for use and contraindications, they provoke the same side effects.
However, unlike its counterpart, Ibuprofen is somewhat better tolerated by children and pregnant women, which makes it possible to use it (albeit with caution) in pediatrics and obstetric-gynecological practice.
Storage conditions and shelf life
The shelf life of the solution for parenteral administration of Diclofenac is 5 years. The drug must be stored out of the reach of children at an air temperature not higher than + 25 ° C.