Amprilan is an antihypertensive agent belonging to the group of angiotensin converting enzyme (ACE) inhibitors.

It has a vasodilating effect, lowers blood pressure. Effective in the treatment of chronic heart failure. After myocardial infarction, the use of Amprilan reduces the risk of sudden death, prevents the development of chronic heart failure. Reduces the likelihood of nephropathy.

On this page you will find all the information about Amprilan: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Amprlan. Want to leave your opinion? Please write in the comments.

Clinico-pharmacological group

ACE inhibitor.

Pharmacy sales terms

It is released on prescription.


How much does Amprylan cost? The average price in pharmacies is about 300 rubles.

Release form and composition

Amprylan is produced in tablets. The drug is sold in blisters of 10 pcs.

Amprylan, 1.25 mg tablets1 tab.
Ramipril1.25 mg
Excipients: sodium bicarbonate, lactose monohydrate, croscarmellose sodium, pregelatinized starch, sodium fumarate.
Amprylan, 5 mg tablets1 tab.
Ramipril5 mg
Excipients: sodium bicarbonate, lactose monohydrate, croscarmellose sodium, pregelatinized starch, sodium stearyl fumarate, a mixture of PB24899 pink dyes (contains lactose monohydrate, iron dye red oxide (E172), iron dye yellow oxide (E172)).
Amprylan, tablets 10 mg1 tab.
Ramipril10 mg
Excipients: sodium bicarbonate, lactose monohydrate, croscarmellose sodium, pregelatinized starch, sodium fumarate.

Pharmacological effect

According to the instructions for use Amprylan enters into the group of ACE inhibitors (angiotensin-converting enzyme). The active ingredient of Amprilan is Ramipril.

This effect of Amprilin as a decrease in pressure and hemodynamics is due to the expansion of blood vessels, a decrease in peripheral resistance (at the same time, the heart rhythm is not lost). With long-term use Amprilana decreases left ventricular hypertrophy.

A decrease in pressure usually occurs one to two hours after a single dose of Amprilan is taken. This effect lasts for another day, and Amprilan’s effect reaches its maximum in three to six hours. According to medical research and reviews, Amprilan reduces the incidence of cardiovascular death, stroke, myocardial infarction in those at risk (suffering from peripheral vascular diseases, diabetes, IHD, stroke), and is additionally susceptible to arterial hypertension, elevated cholesterol, microalbuminuria , tobacco addiction.

According to reviews, Amprilan reduces mortality (in general terms) and the need for revascularization. Amprilan prevents and slows down the development of heart failure (chronic). In diabetics, Amprilan reduces the risk of nephropathy and microalbuminuria.

Indications for use

According to the instructions, Amprylan is shown in the following states:

  • Arterial hypertension.
  • Chronic heart failure, including after myocardial infarction (in combination with other drugs).
  • Diabetic or nondiabetic nephropathy that has developed against the background of chronic diffuse kidney diseases, including chronic glomerulonephritis, accompanied by proteinuria.

Amprilan is also prescribed to reduce the risk of cardiovascular mortality, stroke, myocardial infarction in patients with coronary artery disease who have undergone coronary artery bypass surgery, with occlusive lesions of peripheral arteries.


Contraindications to the use of Amprilan are:

  • Severe arterial hypotension;
  • Metabolic disorders - galactose intolerance, lactase deficiency;
  • Period of pregnancy and breastfeeding;
  • Age up to 18 years;
  • Increased sensitivity of the body to ramipril and other components of the drug;
  • Angioedema in history;
  • Severe renal impairment;
  • Galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
  • Chronic heart failure in the stage of decompensation.

According to the instructions, Amprylan should be prescribed with caution in case of severe circulatory disorders, renal or hepatic insufficiency, diabetes mellitus.

Use during pregnancy and lactation

Presented medicine is prohibited to take in the period of carrying a child due to the fact that it negatively affects the development of the fetus.

The baby may experience kidney problems, hypoplasia of the bones of the skull, hyperkalemia and hypoplasia of the lungs.

Therefore, before you start taking the drug in women of childbearing age, you must eliminate the presence of pregnancy. If a woman is diagnosed pregnant, stop taking Amprilan as soon as possible.

If necessary, the use of the drug at the time of lactation is necessary to completely stop breastfeeding.

Instructions for use Amprilan

The instructions for use indicated that the tablets Amprilan can not be chewed. Taking the drug can be done regardless of the meal. Dosing is selected individually. The tablet must be washed down with clean water in sufficient quantities. Long courses of therapy with Amprilan have been shown.

Dosing schemes drug Amprilan:

Condition, indicationInitial dosage mgMaintenance dosage mgspecial instructions
Arterial hypertension2,52,5-10The dose is carried out 1 time / day. The increase in dose is carried out in 1-2 weeks. With diuretic therapy, it is necessary to reduce the dose of diuretic drugs for three days before the start of therapy with the drug Amprilan
Myocardial insufficiency in the post-infarction period (2-9 days)2,5-55-10The dose is divided into two doses. Doubling doses are carried out every few days. With poor tolerance of dosage at 5 mg / day, the drug is canceled.
Nephropathy associated with diabetes, diffuse pathologies of chronic kidney character1,255Doubling the dose is carried out 1 time / 14 days. The dose is taken once a day.
Reducing the risk of lethal cardiovascular complications2,510Dose doubling is carried out every week.
Indications for patients with renal pathologies (CC less than 30 ml / min)1,255
Indications for Patients with Renal Pathologies1,252,5
Indications in elderly patientsDosing depends on blood pressure indicatorsIt is important to control the patient's condition during diuretic therapy.

Side effects

Amprylan, patient reviews confirm this, may cause some side effects, these are:

  • On the part of the senses: tinnitus, impaired sense of smell, vision, taste and hearing.
  • Since the cardiovascular system: tachycardia, orthostatic collapse, orthostatic hypotension, arrhythmia, decrease in blood pressure.
  • On the part of the genitourinary system: decreased libido, proteinuria, the appearance or strengthening of signs of renal failure.
  • On the part of the digestive system: cholestatic jaundice, nausea, vomiting, intestinal obstruction, dry mouth, glossitis, loss of appetite, stomatitis, hepatitis, pancreatitis.
  • On the part of the respiratory system: rhinorrhea, shortness of breath, bronchospasm, rhinitis, sinusitis, bronchitis, dry cough.
  • On the part of the central nervous system: anxiety, dizziness, tremor, drowsiness, weakness, irritability, frequent mood swings, headaches, muscle spasms, cerebral ischemia, paresthesia.

Also, according to reviews, Amprilan can cause allergic reactions that occur: rash, urticaria, exudative erythema, photosensitization, swelling of limbs, larynx, pharynx, lips, tongue and face, as well as arthralgia, conjunctivitis, myositis, dermatitis, oniholizisom.


If you do not follow the dosage developed by a specialist, then there is an overdose, which is characterized by:

  • significant hypotension;
  • bradycardia;
  • pathological changes in water and electrolyte balance;
  • acute renal failure;
  • shock condition.

Therapeutic measures are aimed at cleaning the gastrointestinal tract, taking drugs with adsorbing properties, sodium sulfate.

Special instructions

  1. For patients with hepatic insufficiency, the initial dose is 1.25 mg, the maximum daily dose is 2.5 mg.
  2. For patients with functional disorders of the kidneys, the initial dose of Amprilan should be 1.25 mg, and the maximum daily dosage should be 5 mg.
  3. Amprilan is taken with caution in patients with systemic diseases of the connective tissue, diabetes, unstable angina.
  4. When taking Amprilan during lactation, breast feeding should be canceled.
  5. If Amprilan is prescribed to patients taking diuretics, it is necessary to cancel or reduce the dosage of diuretic drugs. Also requires constant monitoring of the status of these patients, especially elderly patients (over 65 years).
  6. The drug has a negative effect on the fetus (hypoplasia of the lungs and skull bones, hyperkalemia, impaired kidney function) and is contraindicated in pregnant women. Before discharge Amprilana women of childbearing age, it is important to exclude pregnancy.

Drug interactions

The combined use of Amprilan with some drugs / substances may develop the following effects:

  • Glucocorticosteroids, tetrakozaktid: reduction of antihypertensive effect (due to fluid retention);
  • Potassium preparations, potassium-sparing diuretics, potassium-containing substitutes for edible salt: interaction development (combination is not recommended; regular monitoring of the plasma content of potassium and ECG parameters is necessary);
  • Lithium preparations: the development of a reversible increase in the serum concentration of lithium;
  • Ethanol: increased inhibitory effect on the central nervous system;
  • Vasopressor sympathomimetics (norepinephrine, epinephrine): decrease in antihypertensive effect (with combined use, blood pressure must be carefully monitored);
  • Thiazide diuretics: an increase in the concentration of lithium and the likelihood of its toxic effects;
  • Some remedies used in general anesthesia include: increased antihypertensive effect;
  • Oral hypoglycemic agents, insulin (in diabetes mellitus): increased hypoglycemic effect, increased glucose tolerance (may require correction of their doses);
  • Non-steroidal anti-inflammatory drugs (non-selective COX inhibitors, for example, acetylsalicylic acid in anti-inflammatory doses): decrease in Amprilan's hypotensive effect, increase the likelihood of functional renal impairment, increase in serum kidney function;
  • Antipsychotics (neuroleptics), tricyclic antidepressants: increased antihypertensive effect and increased risk of orthostatic hypotension (additive effect);
  • Immunosuppressants, cytotoxic drugs, procainamide, allopurinol, glucocorticosteroids (for systemic use): an increase in the likelihood of leukopenia;
  • Gold preparation (intravenous administration of sodium aurothiomalate): development of nitrate-like reactions (in the form of nausea, vomiting, flushing of the skin of the face, pronounced decrease in blood pressure).


The drug has established itself as an effective tool in the treatment of heart failure of varying severity. Reviews of tablets indicate good tolerability of the drug and its high efficacy in the treatment of hypertension.


Structural analogues of the active substance:

  • Amprylan NL;
  • Amprylan ND;
  • Vazolong;
  • Dilaprel;
  • Corprile;
  • Piramil;
  • Ramigamma;
  • Ramicardia;
  • Ramipril;
  • Tritatse;
  • Hartil;
  • Hartil D.

Before using analogues consult your doctor.

Storage conditions and shelf life

Amprilan should be stored in a dry place inaccessible to children. 1.25 mg tablets have a shelf life of 2 years, 2.5 mg tablets, 5 mg, 10 mg - 3 years.

Watch the video: Таблетки Амприлан от гипертонии (January 2020).


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